AP22683184 "Investigation of circulating microRNAs as biomarkers of neurodegenerative diseases"

Relevance

With the increasing number of neurodegenerative diseases, the need for effective methods of their early diagnosis is increasing. The use of circulating microRNAs as noninvasive biomarkers opens up prospects for the detection of diseases at the preclinical stage, which makes it possible to start treatment in a timely manner, slow down the progression and reduce the burden on the healthcare system.

Purpose

To study circulating microRNA molecules as diagnostic and prognostic biomarkers of neurodegenerative diseases

Expected and achieved results

Information has been collected on microRNA molecules with increased or decreased differential expression in neurodegenerative disorders. A list of genes associated with neurodegenerative disorders has been compiled. A collection of plasma samples from the blood of patients with neurodegenerative disorders and healthy people (control group) is being formed.

Research team members with their identifiers (Scopus Author ID, Researcher ID, ORCID, if available) and links to relevant profiles

Белкожаев Аяз Маратович

List of publications with links to them

Belkozhayev A. et al. Differential microRNA expression in the SH-SY5Y human cell model as potential biomarkers for Huntington’s disease //Frontiers in Cellular Neuroscience. – 2024. – Т. 18. – С. 1399742.