AP19679937 Synthesis and properties of cellulose nanoparticles and hybrid gels based on alginates with tetracycline/CuO nanoparticles (2023-2025)

Objective of the project

Development of a method for producing a nanohybrid gel based on cellulose nanofibers obtained from rice husks for biomedical purposes, as well as improving the antibacterial and therapeutic properties of the resulting nanohybrid gel by introducing CuO and tetracycline nanoparticles and studying their properties.

Current project status

Microcrystalline cellulose was obtained from rice husk and the optimal conditions were determined. The quality indicators of microcrystalline cellulose were determined. Moisture, ash content, residues of α-cellulose, hemicellulose and lignin were determined. The physicochemical properties of microcrystalline cellulose have been studied using modern methods.

For the first time, cellulose nanofibers were extracted from the rice husk of our country using a new method and hybrid gels were prepared by adding alginate to it. In addition, in order to enhance the antibacterial and therapeutic properties of the resulting hybrid gels, tetracycline and CuO-NB nanoparticles were added, and their properties were fully studied. Using modern research methods, the antibacterial, optical, mechanical properties and physicochemical characteristics, biocompatibility and toxicity of the nanohybrid gel were studied.

Effective use of rice husk, which is an agricultural waste; production of an effective antibacterial hybrid gel with copper oxide nanoparticles for the treatment of skin burns of varying degrees and multiple wounds. The results of the project make a significant contribution to the development of science.

Scientific supervisor: PhD, Kudaibergenov K.K.

Quantitative and qualitative composition of the project performers: 7 performers, including: 3 PhDs, 4 masters.