AP09260760 «Scientific foundations for synthesis and research of elastic and mechanically tough polyampholyte hydrogels for design of adaptive smart materials»
The relevance of the project.
The project is aimed at creating smart hydrogels with special properties for use in medicine and bioengineering as biomaterials and drug delivery systems, among others.
The production and application of such biomaterials have been actively developed in recent decades by research groups around the world, and are thus responsible for much of the current level of development in such fields of knowledge as medicine, pharmaceuticals, cosmetology, biotechnology, agriculture and food processing. The special place of polymers in the creation of biomaterials is confirmed by global sales of $62.1 billion (2015) and $ 115.2 billion (2020) [32]. The use of modern methods for study of the synthesis of PA hydrogels makes possible the achievement of the set goal of the project, the results of which will contribute to the understanding of the processes underlying the creation of new functional hydrogels.
On a national scale, the implementation of this project may allow the future creation of a domestic industry for production of fundamentally new biomaterials for both bioengineering and tissue engineering, thereby establishing a competitive position for the nation in this industry. In addition, implementation of the project may lead to the development of a new scientific direction for research into and synthesis of smart materials.
The main objective of the project:
The aim of the project is to develop a scientific knowledge on elastic and mechanically tough polyampholyte hydrogels based on the anionic monomer of 2-acrylamido-2-methylpropanesulfonic acid (AMPS), cationic monomer 3-acrylamidopropyltrimethylammonium chloride (APTAC), and hydrophilic monomer N, N-dimethylacrylamide (DMA), as well as to study their physicochemical and mechanical properties.
Expected results
Successful implementation of the project can help in the development of a new approach to ensure the production of hydrogels with special elastic properties and self-healing abilities. These could be utilized in the future creation of a new class of gels with adaptive structures, which could be used as anti-thrombogenic materials, wound dressings, or any other sort of substance that needs to be in contact with blood, among others.
Achieved results:
The project aims to create smart hydrogels with special properties for use in medicine and bioengineering as biomaterials, drug delivery systems, etc. In this project, chemically cross-linked equimolar polyampholytic hydrogels based on the anionic monomer AMPS and the cationic monomer APTAC were synthesized and obtained by free radical polymerization. The optimal concentration of the cross-linking agent N, N'-methylenebisacrylamide (MBAA) and the optimal concentration of the SM monomer for gelation were determined. These hydrogels were identified by IR-Fourier spectroscopy and the swelling kinetics of the obtained hydrogels were studied. The rheological method was used to study the gelation points, the modulus of elasticity, and viscosity of the synthesized equimolar polyamapholytic hydrogels. A completely new approach to obtaining hydrogels with special properties like elasticity, elasticity, and self-healing has been determined to create a new class of gels with an adaptive and promising structure in the future.
Names and surnames of the members of the research group with their identifiers:
- Toleutai Gaukhar - scientific supervisor
- Su Espa - leading researcher
- Elemesova Gaukhargul Kairmuhankyzy
- Islam Sholpan Saparbaikyzy - senior researcher